S5: In Silico Approaches/Predictive Toxicology
In Silico Approaches for the Development of Predictive Toxicology
CSIR-Indian Institute of Toxicology Research
The safety assessment of chemicals, drugs and emerging materials is one of the most important issues in regulatory toxicology before bringing them for utilization. The toxicity of chemicals, have been evaluated typically using rodents and inferred to humans. The usage of animals in research, teaching and testing is an ethical issue because of animal welfare. Various in vitro methods, omics, and in silico approaches have been developed as an alternative platform. Few reports show that results obtained from alternative models are efficient and reliable to the animal experiments as well human tests. Although the efforts for complete consideration of alternatives to animal, a great deal of work yet to be carried out to possibly eliminate animal testing experiments. Computer-aided models as alternative animal models are established from molecular level to system level such as structure activity relationships, molecular mechanisms of chemical/drug action, absorption, metabolism and toxicity, interactions with receptors, and cellular/skin simulation models. In this talk, we will discuss the advantage, disadvantage and advancements in in silico modeling on alternative animal models and highlighting some of our predictive approaches on toxicity descriptor development, assays and nano-bio interactions.