S3: characterisation and risk assessment of engineered nanomaterials
eNanoMapper - a knowledge infrastructure supporting the characterisation and risk assessment of engineered nanomaterials
Starting in 2014, eNanoMapper developed a computational infrastructure for toxicological data management of engineered nanomaterials (ENMs) based on open standards, ontologies and an interoperable design to enable a more effective, integrated approach to European research in nanotechnology. eNanoMapper has supported the collaborative safety assessment for ENMs by creating a modular, extensible infrastructure for transparent data sharing, data analysis, and the creation of computational toxicology models for ENMs. eNanoMapper developed resources, tools and standards supporting the development of a scientifically sound risk assessment of ENMs that will support the design of new safe and environment-friendly ENMs as well as the assessment of existing materials. The overall objectives of eNanoMapper were to: a)- Create a modular infrastructure for data storage, sharing and searching, based on open standards and semantic web technologies, minimum information standards and established security solutions; b)- Develop ontologies for the categorization and characterization of ENMs in collaboration with other projects; c)- Create new computational models in nanomaterials safety through the implementation of interfaces for toxicity modelling and prediction algorithms which may process all data made available through eNanoMapper (e.g. using algorithms available from the OpenTox project or statistical/data mining software); d)- Support the meta-analysis of nano-bio interactions supporting “safe-by-design” ENMs development by pursuing a Linked Data approach which integrates data and metadata originating from diverse sources within nanoscience, chemistry, biology and toxicology; e)- Create tools for the exchange, quality assurance and reporting of research protocols and data for regulatory purposes; f)- Create a community framework for interdisciplinary collaboration. In this presentation I will review the progress and results achieved by eNanoMapper over the last 3 years in support of the development of a sustainable knowledge infrastructure supporting the work of the Nano Safety Cluster and international collaboration. I will also discuss how we are extending these resources within the context of two new initiatives: OpenRiskNet which is extending OpenTox as an e-infrastructure supporting risk assessment, and ACEnano where we are developing new eNanoMapper knowledge resources supporting characterisation and reproducible science goals including the development of standards, ontology, terminology, templates, and protocol management.