Meta-analysis for nanotoxicity on Daphnia magna

Meta-analysis for nanotoxicity on Daphnia magna by carbon and metal based nanomaterials


Hyun Kil Shin, Myung Won Seo, Seong Eun Shin, Kwang-Yon Kim, June-Woo Park, Kyoung TaiĀ 


Hyun Kil Shin


Yonsei University, Seoul, Republic of Korea


Daphnia magna (D. magna) is commonly used invertebrate specie in regulatory toxicity testing because of its ecological importance in water ecosystem. To assess the hazard of nanomaterials to aquatic environment, the toxicity of D. magna by nanomaterials has been studied through various experiments. However, parameters causing toxicity to D. Magna are not clearly validated due to the different condition and scope of each experiment. Therefore, massive literature mining, meta-analysis, has been performed to analyse significance of parameters on D. Magna nanotoxicity.

In this study, all available research articles on D. magna nanotoxicity were collected. For the type of nanomaterial, carbon (carbon nanotube, and fullerene) and metal (Ag, Au, Al, Cu, Al2O3, CeO2, CuO, Fe3O4, TiO2, and ZnO) based nanomaterial data were considered together. Data satisfying the standard were used to maintain quality of data. In information extraction process, any parameter which could possibly contribute to nanotoxicity on D. Magna was selected from research article such as properties of nanomaterials like size, hydrodynamic size, zeta potential, shape, and coating materials, and experimental conditions like dispersion method, exposure time, concentration of nanomaterial, number of daphnia, food concentration, and concentration of organic matter in media. For toxicity test results, immobilization test, and mortality test data are collected. By integrating all available information, significance of parameters toward nanotoxicity on D. magna can be assessed.