Session 4 Chair: Kyun-Sun Kang

Dr Kyun-Sun Kang 

Session 3 Chair: Kyun-Sun Kang, OpenTox Asia 2017

Kyun-Sun Kang 


Seoul National University 




The importance of performing drug toxicity screening in the early phase of pharmaceutical development is well known. Currently, human stem cells including iPSC (induced pluripotent stem cells) and iASC (induced Adult Stem Cells) are thought to be useful for the prediction of drug-induced toxicity and for the alternative methods substitute of animal testing. However, the use of primary human cells is restricted, making it difficult to supply the abundant quantities required for large-scale drug toxicity screening. Because of this, there is an urgent need for a novel unlimited, efficient, inexpensive, and predictive model which can be applied for large-scale drug toxicity screening. 

Human stem cells and induced pluripotent stem (iPS) cells are able to replicate indefinitely and differentiate into most of the body's cell types, including hepatocytes, cardiomyocytes and neuronal cells etc. It is expected that somatic-specific functional cells generated from human stem cells will be a useful tool for drug toxicity screening. To apply human stem cells to various applications including drug toxicity screening, homogenous and functional cells must be differentiated from human stem cells. In this session, we will introduce the current status of technologies from human stem cells and a novel method to predict drug-induced toxicity using human stem cells.