S6: Systems Toxicology & Ontologies
How can Systems Toxicology benefit from Ontologies?
Department of Toxicogenomics, Maastricht University
Waters and Fostel (2004) defined systems toxicology as the study of the perturbation of biological systems by chemicals and stressors, monitoring changes in molecular expression and conventional toxicological parameters, and iteratively integrating response data to describe the functioning organism.
Nowadays, there are several definitions for systems toxicology and data integration has become an important part of it.
However, on what level can this integration take place?
What are its limitations at present?
How can ontologies aid the integration of multiple experiments?
Through some examples an answer will be sought for these questions.