Session 3: Toxicogenomics-considering applications

Toxicogenomics-considering applications to predictive toxicology
OpenTox Euro 2014 speaker: Roland Grafström
PRESENTING AUTHOR: 

Roland C Grafström

INSTITUTION / COMPANY : 

Health R&D, Knowledge Intensive Products and Services, VTT Technical Research Centre of Finland, Turku, Finland
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

AUTHOR(S): 

Roland C Grafström, Rebecca Ceder and Pekka Kohonen

WHEN: 
Tue, 23. Sep. 2014

ABSTRACT CONTENT / DETAILS:
Toxicogenomics aims at interdependently analyzing toxicity data and gene expression profiling results for understanding and predicting chemicals toxicity.

This field has advanced surprisingly slowly due to limited comprehensive data collections and lack of innovative approaches to address existing data.

We studied formaldehyde toxicity, as this agent represents an information-rich chemical for which extrapolation of in vitro data to human and animal data is possible.

Formaldehyde toxicity and transformation potency in vitro was analyzed in human epithelial cell lines, including by transcript profiling.

We show new evidences for that toxicogenomics results serves better than traditional toxicity data for elucidating modes of action and for linking exposures in vitro to exposures shown to exert toxicity effects in vivo.