Session 6: Read Across

OpenTox Euro 2014 Session 6: Read Across

Read Across
Session Chair: Barry Hardy, Douglas Connect, Switzerland

Wednesday, 24 September 2014
from 11:00 to 13:00

Speakers Title
Volker Strauß, BASF Metabolomics as tool for read-across
Sylvia Escher, Fraunhofer Institute of Toxicology and Experimental Medicine Use of alternative methods to support read across- experiences form the Detective project
Stefan Kramer, Johannes Gutenberg-Universität Mainz Cascaded Classification and Regression for the Integrated Prediction of Activity/Non-Activity and Degree of Activity
Barry Hardy, Douglas Connect Read Across Use of Alternative Evidence in Replacement Research and Safety Assessment supported by OpenTox and ToxBank

Read Across provides a methodology to use existing evidence on a source chemical or set of chemicals to make toxicological predictions for a target chemical. A traditional Read Across approach typically provides arguments based on a group of compounds having chemical similarity and by inference a common mechanistic basis. Increasing amounts of biological data offer the opportunity to introduce and combine new evidence into Read Across methods.

Read Across provides an important application for industry as the approach may be used within regulatory frameworks such as REACH. In this session we discuss current activities in the development of Read Across approaches and the role that predictive toxicology is playing in their further development and practical application.