Wednesday, 24 September 2014
from 11:00 to 13:00
|Volker Strauß, BASF||Metabolomics as tool for read-across|
|Sylvia Escher, Fraunhofer Institute of Toxicology and Experimental Medicine||Use of alternative methods to support read across- experiences form the Detective project|
|Stefan Kramer, Johannes Gutenberg-Universität Mainz||Cascaded Classification and Regression for the Integrated Prediction of Activity/Non-Activity and Degree of Activity|
|Barry Hardy, Douglas Connect||Read Across Use of Alternative Evidence in Replacement Research and Safety Assessment supported by OpenTox and ToxBank|
Read Across provides a methodology to use existing evidence on a source chemical or set of chemicals to make toxicological predictions for a target chemical. A traditional Read Across approach typically provides arguments based on a group of compounds having chemical similarity and by inference a common mechanistic basis. Increasing amounts of biological data offer the opportunity to introduce and combine new evidence into Read Across methods.
Read Across provides an important application for industry as the approach may be used within regulatory frameworks such as REACH. In this session we discuss current activities in the development of Read Across approaches and the role that predictive toxicology is playing in their further development and practical application.