Session 5: The aryl hydrocarbon receptor

The aryl hydrocarbon receptor and Immunotoxicity
PRESENTING AUTHOR: 

Martin Leonard, B.Sc. Ph.D.

INSTITUTION / COMPANY : 

Public Health England

POSITION: 

Senior Toxicologist

ABSTRACT CONTENT / DETAILS: 

The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor, induced by planar aromatic hydrocarbons to regulate the expression of genes mainly involved in chemical detoxification (e.g CYP1A1, ALDH3A1).

It has also been recently identified that its activation plays a key role in how these chemicals can modify the immune system and cause immunotoxicity.

As a greater understanding of how such immunomodulation occurs, particularly in terms of adaptive immune responses, the ability to develop and refine model systems for the assessment and prediction of chemical immunotoxicity becomes a more informed and valuable prospect.

In this talk, I will describe how endogenous and exogenous ligands of the AHR can impact inflammatory pathways and stress responses as a means to future prediction and understanding of chemical hazards to human health.