Session 5: Modelling Cellular Perturbations & Responses

Session 5: Modelling Cellular Perturbations & Responses

Modelling Cellular Perturbations & Responses
Session Chair: Paul Jennings (Medical University of Innsbruck)

Friday, 2 October 2015
from 9.00 to 10:45

Speakers Title
Alice Limonciel, Medical University of Innsbruck Transcriptomics hit the target: tracking transcription factor activation with sensitive and specific target gene signatures
Eva Szegezdi, NUI, Galway The NEDD8 activating enzyme inhibitor pevonedistat (MLN4924) diminishes paracrine bone marrow stroma-leukemia communication and increases leukemia drug sensitivity
Martin Leonard, Public Health England The aryl hydrocarbon receptor and Immunotoxicity
Roland Grafström, Karolinska Institutet Defining adverse outcome pathways from omics-driven bioinformatics and modeling approaches
Session 5 Summary

Evolution has equipped cells with a variety of strategies to overcome cellular stress and to maintain cell and tissue homeostasis.

Many of these pathways are governed by transcription factor activation, meaning that the initial response to the perturbation is transcription factor activation and transcription of specific downstream genes.

These pathways are tightly controlled with inhibitory proteins and negative feed-back loops. Stress response pathways are key to toxicological outcomes and their activation can be used to characterise chemical reactivity.