Session 6: Linking Parameters & Evidence across Scales

Session 6: Linking Parameters & Evidence across Scales

Linking Parameters & Evidence across Scales
Session Chair: Vladimir Lobaskin (UCD)

Friday, 2 October 2015
from 11.00 to 13:15

Speakers Title
Christoffer Åberg, University of Groningen, Netherlands Kinetics of Nanomaterial Accumulation and Intracellular Transport in Cells and Barriers
Thorsten Auth, Forschungszentrum Jülich, Germany From modeling nanoparticle-membrane interaction towards toxicology
Robert Rallo, Universitat Rovira i Virgili, Tarragona, Spain  Nanomaterial Modelling
Eli Goldberg, ETH Zurich Limitations of data mining and machine learning for toxicology
Session 6 Summary

While statistical analysis often allows one to relate the physical and chemical descriptors of the materials to certain toxicity endpoints, the mechanisms of the toxic action are not always known. The quantitative relations between the descriptors and the effect can only be deduced once we have a clear picture of all stages of interaction between the foreign agent and the biological tissue and of all stages of the systemic transport at the mechanistic level.

The identification of molecular or nanomaterial properties responsible for the uptake or hazard can be facilitated by establishing the molecular initiating events or key events in each adverse outcome pathway and by mechanistic modelling of the underlying processes. This effort is essential for creating sensible predictive schemes in toxicology.