Session 6: Nanomaterial Cellular Kinetics
University of Groningen, Netherlands
Unique characteristics of the nano-scale challenge paradigms underlying safety assessment when applied to nanomaterials, and this must also be reflected in models built to capture, understand and – ultimately – predict nanomaterial hazard.
Notably, an environmentally defined biological identity and cell-energy driven internalisation suggest the need to revisit the basic principles of how nano-scale objects interact with cells and barriers.
We will discuss efforts to build quantitative models for describing nanomaterial-cell interactions, emphasising the unique properties of the nanoscale and how this is captured in the models.
Several examples comparing model predictions and high quality experimental data will be given [1-3], in notable cases showing excellent agreement between experiments and theoretical parameter-free predictions [2-3].
We stress also where physicochemical properties alter the behaviour [4-5].