Session 6: Nanomaterial Cellular Kinetics

Kinetics of Nanomaterial Accumulation and Intracellular Transport in Cells and Barriers
PRESENTING AUTHOR: 

Dr. Christoffer Åberg

INSTITUTION / COMPANY : 

University of Groningen, Netherlands

POSITION: 

Post-doctoral Researcher

ABSTRACT CONTENT / DETAILS: 

Unique characteristics of the nano-scale challenge paradigms underlying safety assessment when applied to nanomaterials, and this must also be reflected in models built to capture, understand and – ultimately – predict nanomaterial hazard.

Notably, an environmentally defined biological identity and cell-energy driven internalisation suggest the need to revisit the basic principles of how nano-scale objects interact with cells and barriers.

We will discuss efforts to build quantitative models for describing nanomaterial-cell interactions, emphasising the unique properties of the nanoscale and how this is captured in the models.

Several examples comparing model predictions and high quality experimental data will be given [1-3], in notable cases showing excellent agreement between experiments and theoretical parameter-free predictions [2-3].

We stress also where physicochemical properties alter the behaviour [4-5].