Session 7: Evaluating systemic toxicity

Addressing repeated-dose systemic toxicity using ToxCast and ToxRefDB data
PRESENTING AUTHOR: 

Gladys Ouedraogo, Pharm.D, Ph.D

INSTITUTION / COMPANY : 

L'Oreal

POSITION: 

Scientific Officer

REFERENCES: 

>> SEE THE PRESENTATION <<

Adler et al., 2011: Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010; Arch Toxicol (2011) 85:367–485

ABSTRACT CONTENT / DETAILS: 

Addressing repeated-dose systemic toxicity with non-animal methods is a substantial research challenge: a state of the art review published in 2011 by Adler et al., concluded that a full replacement of the animal tests used for repeated dose/reproductive and developmental toxicity testing was not available and the timeframe for a full replacement could not be clearly estimated.

Since then, several research initiatives have made progress in Europe and overseas in developing different approaches covering bioactivity with in vitro and in silico methods, adverse outcome pathways and exposure.
To assess this endpoint, a point of departure is needed in lieu of the historical data derived from the animal studies.

This project builds on the data available in ToxRefDB and generated in ToxCast to model repeated-dose systemic toxicity in a pragmatic fashion.

Other features related to the chemical structure like chemotypes and molecular descriptors were also considered.

Each building block of the model will be highlighted and the overall performances obtained will be presented.

Applications of the model will also be discussed.

AUTHORS:
G. Ouedraogo, S. Loisel-Joubert1, L. Truong3, M. Martin2
1 L'Oreal R&I, France
2 National Center for Computational Toxicology, US Environmental Protection Agency, RTP, USA
3 Sinnhuber Aquatic Research Laboratory (SARL), Oregon State University, USA