WG2: Mapping Data Resources to AOPs

AOPs (Adverse Outcome Pathways): Collection and Dissemination with AOP Knowledge Base (AOP-KB) and possible synergies with OpenTox

An AOP is an analytical construct that describes a sequential chain of causally linked events at different levels of biological organisation that lead to an adverse health or ecotoxicological effect. AOPs are the central ele ment of a toxicological knowledge framework being built to support chemical risk assessment based on mechanistic reasoning. AOPs portray existing knowledge concerning the linkage between two anchor points - the Molecular Initiating Event (MIE), and an Adve rse Outcome (AO), connected by a chain of Key Events (KE) and the relationships between them (KER).

To enable the scientific community, in one central location, to share, develop and discuss their AOP - related knowledge, the "Adverse Outcome Pathway Knowl edge Base" (AOP - KB , http://aop - kb.org ) was created. AOP - KB is a crowdsourcing platform managed by the Organisation for Economic Co - operation and Development (OECD): Everyone across the stakeholder community (research, indu stry, regulatory bodies etc.) is invited to contribute their AOP knowledge.

Working Group S ession 2 will raise awareness of the data requirements and their implementation in the AOP - KB on the one hand and data services and format standards proposed by Open Tox on the other. Short presentations of both will set the scene for a discussion on the possible synergy between the OpenTox Framework and its resources and standards, esp. the OpenTox Ontology effort and the OpenTox Data Warehouse (Toxbank). Potential in corporation of other standards like the OECD Harmonized Templates (OHTs) for chemical hazard properties (e.g. the upcoming OHT 201 on "Intermediate Effects") will be covered. Use of OpenTox warehouse data in the AOP - KB to underpin chemical - agnostic AOP kno wledge with real - life chemical data will be discussed . Embracing an open standard approach and third parties that might benefit and potentially use the emerging standard will be identified. Creating a common vision for the use of shared tools and data for the prediction of toxicity is a goal.

The result of Working Group S ession 2 will be an agreement on a way forward to re - use, where possible, OpenTox deliverables in the AOP - KB with a view to cross - fertilization between both areas, especially in the creation of a jointly supported ontology of terms used in both projects.

Workshop Leader: Clemens Wittwehr, Project Co-ordinator at European Commission - Joint Research Centre (JRC)

  Clemens Wittwehr Clemens Wittwehr is responsible for the Data2Knowledge project in the Systems Toxicology Unit of the JRC's Institute for Health and Consumer Protection (IHCP). Data2Knowledge bridges the gap between Information Technology and Life Sciences by enabling res earchers to capture, manage, publish and share their data in a global stakeholder community from science, industry and regulatory bodies. This JRC activity underpins the current paradigm shift in toxicology away from a mere observational science towards an emerging discipline that will provide tools to predict a chemical's toxicity using significantly less animals test and boosting alternative approaches. Earlier in his JRC career, Clemens was also manager of the IUCLID project, which delivered the standa rd software now used by chemical industry to submit their registration dossiers under REACH, the EU chemicals legislation. IUCLID has since been handed over to the European Chemicals Agency (ECHA). Clemens joined the JRC in 2000, after having worked for th ree years in the Informatics Directorate of the European Commission in Luxembourg. Before that, Clemens had worked for the City of Linz, Austria. Clemens graduated in Computer Science and Business Administration from the University of Linz