Session 4 Chair: Chris Evelo

Prof. Dr. Chris Evelo

Session 1 Chair: Chris Evelo

Chris Evelo


Maastricht University




Besides new and improved in vitro methods, in silico plays a major role in the endeavor to reach the 3R goals of replacement, reduction and refinement in both toxicodynamics and biokinetics and especially in the interplay with the first mentioned methods in forming integrated approaches to testing and assessment (IATA) and integrated testing strategies (ITS). However, for the most efficient usage of these methods and making them available to all stakeholder, these tools need to be available and accessible not necessarily in an open (not in the sense of free of charge but of open, interpretable and reproducible science), harmonized and interoperable way. This session will present international approaches and platforms providing discovery services and repositories for predictive-toxicology and risk-assessment software solutions and related disciplines, activities to harmonize the description, access and usage of these and ways to combine them into workflows for more complex analysis and modeling task.

Thomas Exner will start the session with a short introduction to the e-infrastructure OpenRiskNet project, which is co-organizing the session, developing concepts for harmonized application programming interfaces and semantic annotations for input and output. Herve Menager will then describe the ELIXIR registry to ease integration of bioinformatics tools. In her broadcasted talk, Jildau Bouwman will present the specific way how ENPADASI creates data sharing and integration solutions for nutritional studies. We are also delighted that we were able to get Alessia Bardi from the OpenAIRE project presenting their support of “Open Science as-a-Service” for many different communities, which could include our community in the near future. Finally, Marvin Martens will show that events in AOPs typically are described by biomolecular pathways and that there are mechanisms to connect the two.