S5: MECHANISTIC INSIGHTS INTO HUMAN SUSCEPTIBILITY TO NANOMATERIALS
MECHANISTIC INSIGHTS INTO HUMAN SUSCEPTIBILITY TO NANOMATERIALS
Multiple epidemiological and experimental studies have shown that individuals with pre-existing inflammatory conditions are more prone to the adverse effects of environmental injury caused by particulate air pollution. However, only limited experimental data exist on the role of susceptibility in engineered nanomaterial induced toxicity. Nanotechnologies have shown promising potential in multiple sectors of everyday life. These advances span from material science to consumer products. More recently various nanomaterials have proved themselves as excellent candidates for environmental applications. Among these materials cerium dioxide nanoparticles (CeO2 NPs) and multi-walled carbon nanotubes (MWCNT) are priority materials for urgent risk assessment due to wide spread industrial, consumer product and environmental utilizations. Cerium dioxide nanoparticles (nanoceria), currently used as catalysts, including as additives to diesel fuel, also present potential as a novel therapeutic agent for disorders involving oxidative stress. The objective of this talk is to present an in depth analysis into the mode of action of cerium dioxide CeO2 NPs and MWCNT. Acute as well as sub-chronic toxicity data generated using a translation relevant approach by performing ex-vivo exposures on primary human cells isolated from healthy individuals or subjects with pre-existing inflammatory disorders will be discussed. Another focus of this talk will be to elaborate interrelationships between different cell death modalities and inflammatory signaling after nanomaterial exposures.