OpenTox USA 2017 Program

Application of in vitro-in silico Approaches in Toxicology, Safety Assessment and Regulation

WEDNESDAY, 12 July 2017

08.00    Breakfast 
08.30   Opening Remarks 
08.45   S1.
Application of Omics Data in Safety Assessment, Chair: Richard S. Paules (NTP) 
09.00  
Use of genomic dose-response for hazard characterization at the NTP, Scott Auerbach (NIEHS)
09.25  
Implications of population genetic diversity for safety assessment, David Reif (NCSU)
09.50  
Weighted Gene Co-Expression Network Analysis, James Stevens (Eli Lilly)
10.15  
The Resolution of Concentration Response: High Throughput Transcriptomics, Stephen S. Ferguson 
10.45   Coffee Break 
11.00 S2.
11.10  
Why Data Interoperability Matters to Warfighters and First Responders, Lyle Burgoon (US Army Engineer R&D Center)
11.45   Toward Semantic Interoperability of Public Available Data Sources, Thomas Exner (Douglas Connect)
12.10  
DSSTox: The Open Environmental Chemistry Data underlying the Comptox Chemical Dashboard, Chris Grulke (US EPA)
12.35  
Data curation and its role in supporting integration and interoperability, Carolyn Mattingly (North Carolina State)
01.00   Lunch & Poster Session 
03.00 S3. Data-driven development of AOP knowledge, Stephen Edwards (US EPA)
03.15   
Navigating through the minefield of read-across: from research to practical tools, Grace Patlewicz (US EPA)
03.40  
Modeling the Tox21 10K chemical profiles,  Ruili Huang, (NCATS, NIH)
04.05   Development and Use of Quantitative AOPs to Support Decision Making, Ed Perkins (US Army Engineer R&D Center)
04.30   Building AOPs for Arsenic-Induced Developmental Outcomes for Improved Risk Assessment, Rebecca Fry (UNC)

THURSDAY, 13 July 2017

08.00    Breakfast
09.00 S4. Integrated Approaches to Testing and Assessment, Nicole Kleinstreuer (NTP/NIEHS)
09.15  
Multivariate models for skin sensitization hazard and potency, Judy Strickland (NTP/NIEHS)
09.40  
Computational approaches to acute mammalian systemic toxicity, Dan Wilson (Dow)
10.05  
Pathway-based models for rapid screening of endocrine disruptors, Nicole Kleinstreuer (NTP/NIEHS)
10.30   Coffee Break 
11.00 S5.
11.15  
Applying Aggregate Exposure Pathway and Adverse Outcome Pathway to link toxicity testing data, Cecilia Tan (US Environmental Protection Agency)
11.45  
Mechanistic insights into human susceptibility to nanomaterials, Salik Hussain (NIEHS/NIH)
12.15  
Environmentally Relevant Exposures of Nanomaterials in Various Life Stages using Japanese Medaka, David Hinton (Duke University)
01.00   Lunch 
02.00  
Knowledge Cafe & Panel discussions and break-out sessions 
04.00  
OpenTox Association Business Meeting
18.00   Conference ends