S1: Genetic Association Mapping in Cell Line Models
Genetic Association Mapping in Cell Line Models of Cytotoxic Response
Department of Statistics at North Carolina State University
The investigation and discovery of genetic factors that determine differential drug response is the fundamental goal of toxicogenomics. Practical and ethical limitations studying cytotoxics in either application have motivated the use of lymphoblastoid cell line model(s) for high throughput genetic association studies. We present the results of genome-wide assocation mapping studies for a large number of commonly used chemotherapy agents and environmental chemicals, along with the methods development studies behind the high throughput mapping. This GWAS screen produced interesting potential candidate genes, and we present initial results of functional/clinical follow-up of these candidates. We will also present the expansion of this model system to evaluate combinations of drugs and chemicals.