Three important phases of drug development are discovery, toxicological assessment and clinical application. Each of these phases is subject to varying degrees of rigorous science and regulatory review.
Acceptance of alternative (non-animal) methods for regulatory decision making is typically context dependent and relies on many factors.
The overall objective of the EU CarcinoGenomics project was to develop novel in vitro cell based systems to detect and identify cancer causing compounds using transcriptomics, metabolonomics and systems biology with the...
PCR is a common and often indispensable technique used in medical and biological research labs for a variety of applications.
Real-time quantitative PCR (RT-qPCR) has become a definitive technique for quantitating differences in gene expression levels between samples. Yet, in spite of this importance, reliable methods to quantitate nucleic acid amounts in a higher throughput remain elusive.