Roland Grafström works as Professor in Risk Assessment at the Karolinska Institutet since 2000. His speciality is biocomputing and informatics for toxicogenomics, cancer biology, personalized medicine and safety-by-design work.
S2: Translational Bioinformatics
Standardization of pathway analysis methods is perhaps the most urgent need to regulatory application, and benchmark dose analysis might require further developments. Establishing practices for open code and data sharing is a further point.
Analysis of transcriptome changes has become an established method to characterize the reaction of cells to toxicants and are increasingly accepted for in vitro alternative test methods. The qualitative analysis of transcriptome changes
A major goal of human in vitro toxicogenomics is to improve the assessment of the toxic hazard (and ultimately the risk) of drugs, chemicals and other compounds with assays based on human cell lines rather than in vivo in rodents.