Accomplished research software developer with an interdisciplinary doctorate in motor control and artificial intelligence. Strong background in mathematics, algorithm development and computer visualization. Over 20 years of experience with design and implementation of innovative modeling software.
S4: Development & Application of AOPs
Within the kidney, the proximal tubule (PT) is particularly sensitive to xenobiotics due primarily to its multiple uptake routes that include megalin/cubilin, organic anion transporters, peptide transporters and organic cation transporters.
The need for a mechanistic understanding of the toxicological pathways lead to the development of Adverse Outcome Pathway (AOP) program by OECD. AOPs are structural representations of biological key events initiatied by a stressor and leading to an adverse outcome.
The growing interest in Adverse Outcome Pathways (AOP) as pragmatic organizing principle of existing toxicological information has produced a broad range of research ideas from practical rules how to build AOPs to their use as part of networks for predictive purposes.