Clemens Wittwehr is responsible for the Disseminate project in the Chemicals Safety and Alternative Methods Unit of the JRC's Directorate for Health, Consumers and Reference Materials. The Disseminate project bridges the gap between Information Technology and Life Sciences
S6: AOPs and Protocol Ontologies
Waters and Fostel (2004) defined systems toxicology as the study of the perturbation of biological systems by chemicals and stressors, monitoring changes in molecular expression and conventional toxicological parameters, and iteratively integrating response data to describe the functioning organism.
Nowadays, there are several definitions for systems toxicology and data integration has become an important part of it.
NCBO BioPortal lists currently 517 different ontologies ranging from very general like the Units of Measurement Ontology to more specific like the Ontology of Adverse Events. Still, new ontologies are developed all over the world and they are part of many new project proposals submitted to funding agencies.
The Adverse Outcome Pathway Knowledge Base (AOP- KB, http://aop-kb.org) is a crowdsourcing multi-module platform aimed to support the collaborative development, sharing, and dissemination of AOP-related knowledge