The goal of this project is to determine whether inclusion of non-disease phenotypes in CTD could advance: understanding of environmental disease progression, identification of exposure biomarkers, and the capacity to conduct and interpret studies across species and experimental systems.
The program involves conference sessions, hands-on workshop activity, poster session and knowledge café.
Several examples will be presented using such knowledge-informed features to convey associations within a chemical use category (flame retardants), and various HTS and in vivo activity subsets.
The computational models built within this Challenge are expected to improve the community’s ability to prioritize novel chemicals with respect to potential concern to human health.
More specific goals are to identify patterns of compound-induced biological response in order to characterize toxicity/disease pathways, prioritize compounds for more extensive toxicological evaluation, and develop models predictive of adverse health ...