Poster: Predictive Toxicology Tools

Predictive Toxicology Tools Application in Contaminated Sites Health Risk Assessment and Remediation
AUTHORS: 

Barry Hardy (Douglas Connect GmbH, Switzerland), Asish Mohapatra (Health Canada)

PRESENTING AUTHOR: 

Barry Hardy, Douglas Connect GmbH, Switzerland

POSTER ABSTRACT: 

Health Canada (HC) has developed a tool that lists remediation technologies and a decision matrix for evaluating chemical exposure issues. We reviewed current practices involved in the design and intended use of the tool, evaluating the use of various toxicology data resources and predictive tools in providing value to risk management decision making, including the use of human health risk characterization data and tools in remedial alternatives and option analyses.

We evaluated a number of chemicals from Petroleum Hydrocarbons (PHCs), Polycyclic Aromatics Hydrocarbons (PAHs), Chlorinated Hydrocarbons (CHCs), and Perfluorinated chemicals (PFCs). The research included consideration of the physical and chemical properties of the contaminants, reactivity, fate and transport, and the spatial and temporal exposure analysis including analysis of multiple sources of in silico, in vitro, and in vivo data and consensus models under a Weight of Evidence framework.

The methodology was applied to case studies by selecting specific remedial technologies (e.g., bioremediation and chemical based remediation) and prioritizing site-specific contaminants and used to support risk-based predictions and recommendations for management of the contaminated sites.

We were able to integrate relevant background knowledge, new data and predictive models on those test chemicals from publicly available toxicology databases and resources including OpenTox, ToxBank, Comparative Toxicogenomics Database, TG-GATES, SEURAT, PubChem, and Tox21 databases for risk assessment and management decision-making supported by the remediation tool for contaminated sites and identified data gaps and limitations in applications.