Session 2: OpenTox Data AOPs

Using OpenTox to map Toxicity Data to AOPs
Barry Hardy Ph.D., Douglas Connect GmbH, Switzerland
PRESENTING AUTHOR: 

Barry Hardy Ph.D.

INSTITUTION / COMPANY : 

Douglas Connect GmbH, Switzerland

ABSTRACT CONTENT / DETAILS: 

OpenTox provides a framework where data and model predictions can be retrieved from a federated set of data sources.

In this presentation we will discuss the concept of using relevant information (including its retrieval and organisation from multiple sources) in the development and application of Adverse Outcome Pathways (AOPs).

Analysis and discussion of the information obtained were used in conjunction with a collaborative wiki based approach to AOP development and interpretation.

We discuss the requirements and prospective solutions for the further computational development of AOPs e.g., using data and metadata to semantically annotate AOP nodes, challenge limitations in an AOP or propose new nodes for the AOP.

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