Session 3: Exposure Modeling Overview
U.S. Environmental Protection Agency
Recent advances have been made in high-throughput (HTP) toxicity testing, e.g. from ToxCast, which will ultimately be combined with HTP predictions of exposure potential to support next-generation chemical safety assessment.
Rapid exposure methods are essential in selecting chemicals for
1) targeted toxicity testing,
2) higher-tier exposure assessments, and
3) biomonitoring studies.
Unfortunately, for the majority of chemicals in Phase II of ToxCast and beyond (i.e., non-pesticide environmental compounds) there are no available estimates of exposure.
Therefore, the U.S. EPA is developing scientifically-defensible HTP methods for developing quantitative or semi-quantitative exposure predictions, analogous to HTP toxicity methods.
This session will discuss advances in exposure modeling and informatics, including SHEDS-HT, ExPriori (dose ranking), computational exposure sciences (including chemical and exposure space principal components), and new product-use data sources.