Session 4: Screening for Endocrine Disrupting Potential

High Throughput Chemical Screening for Endocrine Disrupting Potential
David Dix, Ph.D. Director, Office of Science Coordination & Policy

David Dix, Ph.D. Director


Office of Science Coordination & Policy, US EPA


The US Environmental Protection Agency (EPA) Endocrine Disruptor Screening Program (EDSP) uses a two-tiered approach to determine a chemical’s potential to interact with estrogen, androgen, and thyroid (EAT) hormone pathways in humans and/or wildlife.

Requirements for testing, data review, and weight of evidence determination require substantial temporal, financial, animal, and human resources. Currently, more than 10,000 chemicals are in use and 100s of new chemicals are introduced every year, necessitating a more rapid method for screening the “chemical universe”.

To address this need, EPA is leveraging in vitro and in silico computational tools to identify potential interactions with EAT pathways.

These data will be evaluated in a hypothesis-driven, adverse outcome framework, proposed to the OECD Adverse Outcome Pathway Workgroup as a harmonized conceptual approach. Resulting hazard identification data will be coupled with estimates of physiologically and environmentally relevant exposure data to produce an integrated and exposure ranking (IBER) to prioritize chemicals for EDSP screening.

This approach facilitates rapid identification of endocrine disrupting chemicals that are likely to have the greatest potency and pose the greatest risk to human and environmental health.

(This abstract does not necessarily reflect EPA policy)