Complement your findings, Step 10

Complement your findings with predicted associations with hepatobiliary adverse events

We have used Pharmatrope's Titanium Models to predict the association of the TCAMS compounds with 19 selected hepatobiliary adverse events:

Hepatic function abnormal Yellow skin
Liver disorder Hepatic failure
Cytolytic hepatitis Hepatitis fulminant
Hepatitis Acute hepatic failure
Hepatitis acute Hepatorenal failure
Hepatitis toxic Hepatotoxicity
Cholestasis Hepatomegaly
Jaundice Hyperbilirubinaemia
Hepatitis cholestatic Hepatosplenomegaly
Jaundice cholestatic  

Complement the your findings on the TCAMS subset using the file at this link. The document contains a list with each compound of the TCAMS subset we have worked with in this exercise, together with the number of adverse events (out of the 19 listed above) Titanium predicts each compound to be associated with (only associations considered statistically relevant are counted).

Please fill out the Evaluation Form.

STEPS:
Step 1: Creation of an OpenTox dataset from a local file
Step 2: Selection of models available in OpenTox through ToxPredict
Step 3: Application of the selected models to the uploaded dataset
Step 4: Obtaining simple statistics for the predictions obtained for the uploaded dataset
Step 5: Adding the predicted values to a tabular view of the dataset and downloading the table
Step 6: Additional steps I) Applying an individual model to a dataset
Step 7: Additional steps II) Searching a dataset according to prediction values
Step 8: Additional steps III) Obtaining additional predictions
Step 9: Additional steps IV) Downloading data from other dataset services in OpenTox
Step 10: Complement your findings with predicted associations with hepatobiliary adverse events

 

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