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Contact Info
Dr. R. Parthasarathi
Computational Toxicology Facility, Centre for Innovation and Translational research

Abstract OpenTox Asia 2019

Non-testing Methods for Toxicity Assessment

Computational approaches continue to increase in capability and applicability in the area of predictive toxicology and plays a vital role in the assessment of safety/toxicity of chemicals. In silico tools with advanced methodology are utilized in various stages of the development of substance by predicting properties that correlate with toxicity endpoints, structure activity relationship models for new chemical formulations, chemical databases construction and retrieving information to provide actionable insights. This talk covers different aspects of computational approaches that focuses on computational toxicology that aims to complement prevailing in vitro /in vivo toxicity tests to predict toxicity and prioritize chemicals/drugs to minimize harmful effects. The state-of-the-art computational approaches used in predictive toxicology will be highlighted in this talk. Special attention will be focused on the usefulness of quantitative structure activity relationship models for genotoxicity prediction in few emerging area of applications for toxicity prediction.