OpenTox Virtual Conference 2021 Session 4 Summary
Genotoxicity Modelling and Testing
New validated in vitro methods and modeling approaches are necessary to increasingly replace the use of animals in genotoxicity tests for the purpose of safety assessment.
The genotoxicity session is designed to provide an overview of recent advances in the development of in vitro and in silico approaches. The session will cover the development of a genotoxicity database based on Ames testing that enables improved prediction of genotoxic substances, the validation of in vitro methods using 3D reconstructed human tissue, and recent progress in the field of in silico models, including Quantitative Structure-Activity Relationship (QSAR) models.
CV: Dr. Paula Braun has a Ph.D. in biochemistry from the Weizmann Institute of Science and has many years of experience working towards the research, development, and validation of novel in vitro testing methods. She advises the Science Consortium on animal testing and non-animal methods, particularly for genotoxicity testing.