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OpenTox Euro 2017 Conference Program

Collaboration and integration: Toxicology and risk assessment in the time of dynamic data

Tuesday, 21 November 2017 (Stucki, Merkur & Mars)

OpenRiskNet Training:
Possible training units offered in the morning or afternoon session depending on interest:  

  • 1. Semantic/ontologies: Georgios Gkoutos and Egon Willighagen
  • 2. Biokinetics modelling: Frederic Bois and Ahmed Abdelaziz
  • 3. Workflow management systems (nextflow, squonk): Tim Dudgeon and Cedric Notredame
  • 4. Online modelling with Jaqpot: Philip Doganis (NTUA)
  • 5. QSAR and conformal predictions (CPSign, ModelingWeb): Ola Spjuth

11.00 - OpenTox - OpenRiskNet Training Session 1

13.00 - Lunch 

14.00 - OpenTox - OpenRiskNet Training Session 2

16.00 - Coffee Break 

16.30 - Data Hackathon: Introduction to Case Studies, API Hackathon: Introduction to API concept and current state of implementation in selected software 

17.30 -Socializing 

Wednesday, 22 November 2017 (Stucki, Saturn 1 & 2) 

08.30 - Continuation Data and API Hackathons 
11.00 - Begin OpenTox Euro Conference - Welcome Remarks 
11.15 - Key Talk: If we all jump together, could we make the earth move?
Chris Evelo (Maastricht University)

12.00 - Session 1: Defined approaches towards regulatory acceptance (Co-organized by in3), Chair: Martin Wilks, SCAHT

  • 1. Etienne Vermeirssen: In vitro and in vivo bioassays in environmental monitoring
  • 2. Rex FitzGerald: Test guidelines, AOPs and IATA - current and future

13.00 - Lunch 
14.00 - Session 2: Simulations of exposure and transport (Co-organized by SmartNanoTox), Chair: Vladimir Lobaskin, UCD

  • 1.Vladimir Lobaskin: The SmartNanoTox project
  • 2.Luca Monticelli: Effect of hydrophobic pollutants on biological membranes: a simulation perspective
  • 3.Vladimir Lobaskin: Modelling bionano interactions for predictive toxicology
  • 4.Giancarlo Franzese: How the Protein Corona Evolves on a Nanoparticle

15.30 - Coffee Break 
16.00 - Session 3: Characterization of experimental conditions, part 1: nanomaterials (Co-organized by ACEnano), Chair: Iseult Lynch, University of Birmingham

  • 1. Iseult Lynch: The ACEnano project and NanoCommons
  • 2. Andrew Nelson: Towards a third generation platform
  • 3.Iseult Lynch: Approaches to the standardization of nanomaterial characterization methodologies – the ACEnano toolbox
  • 4. Iseult Lynch: Characterisation of intrinsic and extrinsic nanomaterial characteristics: the need for relevant exposure media supplemented with appropriate biomolecules

17.00 - OT Development and Activities 
18.00 - Poster Session / Social Event 

Thursday, 23 November 2017 (Stucki, Saturn 1 & 2)

08.30 - Session 4: Integration and interoperability: software (Co-organized by OpenRiskNet), Chair: Chris Evelo (Maastricht University)

  • 1. Thomas Exner: The OpenRiskNet project
  • 2. Herve Menager: Easing the integration of bioinformatics software and services with the ELIXIR registry
  • 3. Jildau Bouwman: ENPADASI: Data sharing and integration solutions for nutritional studies
  • 4. Alessia Bardi: OpenAIRE services in support of “Open Science as-a-Service”  
  • 5.  Marvin Martens: Enriching Key Events in Adverse Outcome Pathways with links to biomolecular databases to allow experimental data analysis for regulatory risk assessment

10.30 - Coffee Break
11.00 - Session 5: Integration and interoperability: data, Chair: Clemens Wittwehr, JRC

  • 1. Johanna McEntyre: ELIXIR Core Data Resources
  • 2. Thomas Exner: Towards Semantic Interoperability of Publicly Available Data
  • 3. Clemens Wittwehr: OECD Harmonised Template 201 – the missing link between AOP science and regulatory acceptance
  • 4. Laura Suter-Dick: Liver fibrosis: Corroboration and improvement of the existing AOP using in vitro data
  • 5. Yaakov Nahmias: Beyond the Chip: Development of a Micro-physiological Flux Analyzer

13.00 - Lunch 
14.00 - Session 6: High-content imaging (Co-organized by EU ToxRisk), Chair: Bob van der Water, Leiden University

  • 1. Bob van der Water: The EU-ToxRisk project
  • 2. Laura Purdie: Advances in high content imaging in toxicology: 2D and 3D cell-based models
  • 3.Johannes Delp: Application of high content imaging in screening approaches to detect potentially neurotoxic compounds
  • 4. Bob van der Water: Quantitative high throughput microscopy of adaptive stress responses in chemical safety assessment

15.30 - Coffee Break 
16.00 - Session 7: Characterization of experimental conditions, part 2: cell models, Chair: Iseult Lynch, University of Birmingham

  • 1.Paul Jennings: The MSCA-ITN in3 project
  • 2.Podium discussion on phenotypic characterization of iPS cell derived models with short introduction to the cell models

17.30 Final Remarks 
18.00 Meeting Adjourned