OpenTox USA 2018 Program

Conference Theme: Maximizing the Benefits of In Vitro- In Silico Approaches in Toxicology and Risk Assessment in an Ever Changing Data Landscape.

Venue: North Carolina Biotechnology Center, Durham, NC, USA

Dates: July 11-12, 2018 

Organising Committee: Dr. Stephen Edwards (RTI International), Dr. Annie Jarabek (U.S. EPA), Dr. Barry Hardy (Douglas Connect), Dr. George Woodall (U.S. EPA), TJ Bozada (Toxtrack), Brendan Hardy (Douglas Connect) and Dr. Noffisat Oki (Douglas Connect).

Wednesday, 11 July 2018

North Carolina Biotechnology Center, Raleigh-Durham, North Carolina

08.00   Registration
Welcome Remarks - Noffisat O. Oki, Ph.D. (Douglas Connect, Durham NC, USA) OpenTox NC Local Chapter President.
09.00 S1. Precision Medicine and Applications in Predictive ToxicologyChair: Stephen Edwards, Ph.D. (RTI International, Durham, NC, USA)
Alison Motsinger-Reif, Ph.D. (North Carolina State University, Raleigh, NC, USA) Genetic Association Mapping in Cell Line Models of Cytotoxic Response
Deepak Voora, MD (Duke University, Durham, NC, USA) Systems Pharmacogenomics of Aspirin: A new take on an old exposure 
Sara Imhof, Ph.D. (North Carolina Biotechnology Center, Durham, NC, USA) The Value of Collaborative Models and Partnerships for Advancing Precision Health
10.50   Coffee Break 
11.10 S2. Reproducibility of In Silico Analysis in Predictive Toxicology, Chair: Huixiao Hong, Ph.D. (U.S. Food and Drug Administration)
Nisha Sipes, Ph.D. (NTP/NIEHS, Research Triangle Park, NC, USA) Concordance in Modeling Concentration-Response Data: Tox21 10k Library Pipeline Comparison
Ping Gong, Ph.D. (US Army Engineer R&D Center, Vicksburg, MS, USA) Quantitative Target-specific Toxicity Prediction Modeling
Marco Chierici, Ph.D. (Bruno Kessler Foundation, Trentino, Italy) Deep Learning for Predictive Toxicology
Xiaohui Fan, Ph.D. ( Zhejiang University, Hangzhou, Zhejiang Province, China) How to Choose the Right Cancer Cell Line for Your Research: a Transcriptomes-guided Approach
01.00   Lunch - will be served in the Dogwood Room of the conference center and posters will be available for viewing in the lobby.
02.00  S3. Poster Platform SessionChair: Noffisat Oki (Douglas Connect, USA)  
    The platform presenters:
sp.1    Prachi Pradeep, Ph.D. (NCCT) Development of QSAR Models for Systemic Toxicity Points of Departure with Variability in Experimental Data
sp.2   Danica E. DeGroot (NCCT) Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence Using Alginate Immobilization of Metabolic Enzymes (AIME)
sp.3   David Crizer (NTP, NIEHS) The in vitro disposition of Tox21 Chemicals 
  Discussion - OpenTox Association business meeting
04.50   Conference day 1 closing remarks
06.30   Conference dinner/reception

Thursday, 12 July 2018

North Carolina Biotechnology Center, Raleigh-Durham, North Carolina

09.00 S4. Ontologies for Interoperability of Data in Predictive Toxicology, Risk and Safety Assessment, Chair: Helen Pan, Ph.D (RTI International, Durham, NC, USA)
sp.1   Stephan Schurer, Ph.D. (University of Miami, Miami, Florida, USA) Data Standards, Ontologies, and Software Tools for FAIR Open Data
sp.2   Deborah L. McGuinness, Ph.D. (Rensselaer Polytechnic Institute, Troy, NY, USA) Building, Using and Maintaining Ontology-enabled Resources in Exposure Science and Health Informatics Settings
sp.3   Chris Mungall, Ph.D. (Lawrence Berkeley National Laboratory, San Francisco, CA, USA) Modeling Exposure Events and Adverse Outcome Pathways Using Open Biological Ontologies
sp.4   Helen Pan, Ph.D. (RTI International, Durham, NC, USA) Extension and Application of Exposure Ontologies in Linking Complex Disease and Exposure Data to Established Data Standards
10.50   Coffee Break System
11.10 S5. Open Data Standards and Data Sharing Principles for Enabling Predictive Toxicology Collaborations, Chair: Annie Jarabek (U.S. Environmental Protection Agency, RTP, NC, USA)
Christine Hendren, Ph.D. (Duke University, Durham, NC, USA) Data Harmonization and Sharing in the Nanoinformatics Community: Navigating convergence within the incentive structures of research efforts
Rebecca Boyles, MSPH (RTI International, Oxford, United Kingdom) The NIH Data Commons: A novel infrastructure to support data sharing
Carolyn Mattingly, Ph.D. (North Carolina State University, Raleigh, NC, USA) Leveraging and Integrating Standardized Language for Predictive Toxicology
Yvonne Dragan, Ph.D. (Takeda, Cambridge, Massachusetts)  Innovation Tools and Approaches for Safety Applications
Lunch - will be served in the Dogwood Room of the conference center.
  Choose-Your-Hack Discussion Session: Chaired by Stephen Edwards (RTI International, Durham, NC, USA) and Annie Jarabek (U.S. Environmental Protection Agency, RTP, NC, USA)
    This discussion session will involve audience participation focusing on open data standards, data sharing and the role of ontologies. The session starts with strategies and lessons learned from the morning speakers to stimulate ideas for discussion. This will be followed by a series of short presentations on potential use cases that will be carried forward for more rigorous and in-depth examination in planned future hackathon(s). Example Use Cases should illustrate strategies for approaching data sets and other challenges of data or model integration and implementation in workflows. 
    Use case selection criteria for the hackathon include the following:
I.   Clearly defined problem with a specific scope
II.   Impact of the potential improvement on your processes if we are successful in addressing your use case/problem.
III.   The data required must be easily accessible/available to the participants.
IV.   Level of interest at the meeting (i.e. how many people at the meeting would be willing to participate and attend the hackathon)
04.00   Poster prize presentation and closing remarks
04.30   Meeting adjourned