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Mechanistic Investigations

OpenTox Virtual Conference 2020 Session 17 

The need for non-animal and more predictive toxicity tests in drug discovery provides drivers for new methods of chemical screening. This session focuses on various in vitro techniques including stem cells based methods and also the Adverse Outcome Pathway (AOP), a framework that describes a continuous chain of causally associated key events with the interaction of stress factors with biomolecules that lead to an adverse health effect at different levels of biological organization. Also, in this session, we will discuss current efficient approaches for generating kidney and liver cells in vitro and their applications in regenerative medicine and drug discovery.