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Contact Info
Thomas Luechtefeld
Insilica

Thomas Luechtefeld is a specialist in the development of AI-driven systems for predictive toxicology. His current work focuses on the "Persistent Agent" framework, which integrates large language models, interoperable knowledge graphs, and predictive tools to automate toxicological reasoning. By leveraging platforms like ToxIndex and the BioBricks-OKG data registry, Thomas aims to turn fragmented data into coherent, interpretable predictions for safer material design and hazard assessment. He is an active contributor to the OpenTox community, dedicated to advancing scalable, automated approaches for chemical safety and regulatory compliance.

OpenTox Summer School 2026

Abstract

Agentic systems are transforming how all domains of knowledge operate. In this presentation we will discuss how retrieval systems, computational models, and agentic loops can all work together to support research and generate value through automated workflows. We'll talk about some of the challenges and solutions to validating agentic outputs and share how to use the toxindex suite in your own agentic coding environment.